Paper published in Molecular and Cellular Neuroscience (mitochondria in axons)

The paper “Intermitochondrial signaling regulates the uniform distribution of stationary mitochondria in axons” was published in Molecular and Cellular Neuroscience 119, 103704 (2022). doi:10.1016/j.mcn.2022.103704

Stationary mitochondria were observed to be distributed relatively uniformly along axons. Local inactivation of mitochondria by light reduced the motility of nearby mitochondria, suggesting that functional mitochondria enhance the motility of other mitochondria in their vicinity. A mathematical model showed that the ATP gradient generated by mitochondria and ATP-dependent regulation of their motility can produce a uniform distribution. The work was a collaboration with experimentalists; Kajita developed the model.

The work is also described on the Research page.